Isogenica has two proprietary technologies:
CIS display: a powerful cell-free DNA display discovery platform enabling libraries sizes in excess of 10^13 to be displayed. The company has recently been applying next generation sequencing technology to comprehensively screen in silico peptide aptamer repertoires.
Colibra: a proprietary approach for generating highly functional codon-based libraries for protein engineers that enable greater precision in the design, greater functionality, less screening effort and better efficiency over current degenerate methods.
Technology names: CIS display; Colibra
Nature of molecules: Peptides, scaffolds, antibody
Selection methods: CIS display, phage.
Time required for binder selection on a given antigen: approximately 6 weeks, target dependent
Throughput capacity per year: >24, depends upon product requirement
Average number of molecules selected on a given antigen: 10-100
Affinity range of the selected molecules: 100pM-1μM
Number of successful selection performed so far: >35
Functional molecules selected on a given antigen: Antigens are confidential but successful selections include GPCRs, kinases, cytokines, receptors, enzymes, microbes, intracellular proteins